The global adoption of remote work, accelerated by the COVID-19 pandemic, has fundamentally transformed occupational structures and daily routines. While flexible work arrangements offer potential benefits, including increased autonomy and reduced commuting stress, emerging evidence points to significant psychological challenges. This article critically examines the impact of remote work on mental health, integrating empirical findings from cross-sectional, longitudinal, and meta-analytic studies. A conceptual model is proposed to highlight mediators such as social isolation, digital fatigue, and blurred work–life boundaries, alongside moderating variables including personality, home environment, and organizational culture. Evidence-based interventions ranging from hybrid work models to structured communication protocols are evaluated. A conceptual model is proposed to highlight mediators such as social isolation, digital fatigue and blurred work. Life boundaries, alongside moderating variables including personality, home environment and organizational culture. The paper concludes by emphasizing the need for sustainable strategies that balance flexibility with psychological well- being, positioning mental health as both a moral responsibility and a determinant of long-term productivity.